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Nah that info is based on the original strain. For delta we simply don't know, there's not been enough research done, the strain is still relatively new.Quote:
Originally Posted by Ziggurat
The reason why it makes sense to get your second AZ early is that delta is at risk of running rampant soon.
If you get the second early its efficacy might fade quicker, but that doesn't matter so much if we get boosters next year. The important thing is surviving this year.
I think this may be the one you want, published Feb 2021.Quote:
Originally Posted by Markin
https://www.thelancet.com/journals/l...432-3/fulltext
You'll find this text in the "Discussion"
"In our study, vaccine efficacy after the second dose was higher in those with a longer prime-boost interval, reaching 81·3% in those with a dosing interval of 12 weeks or more versus 55·1% in those with an interval of less than 6 weeks."
For the layman, you can always cover the gap of the "don't know yet" with a bit of common sense. The scientific and academic fraternities may not be at liberty to do so, but you are free to make your own judgement using common sense.Quote:
Originally Posted by MisterWhippy
If the vaccine can be more effective against the original strain simply by waiting 1 week longer for the second dose, surely the same effect would apply to the Delta strain. At worst it wouldn't be any more effective, but what's the likelihood of that outcome?
If your argument is that the longer you wait the more likely you'll get infected before the second dose, then let common sense fix THAT too. In this 1 week.... That's 7 days in total only... You just bury yourself at home, completely Zero contact with the outside world. You know it's going to go rampant, why go out before the second dose?
have a look how Moderna's stock price has travelled over the last 3.5 months (152% up since 1 May) - I'll be punting on those profits for a couple years when conditions permit!
Common sense arguments are rarely worth sharing though, they're too arguable. "Do you have any evidence for that?" Shrug.Quote:
Originally Posted by GoldfishMan
Also there's the context in this thread, that we're arguing about the advice of medical professionals, questioning that advice based on information known to be out of date. Is that sensible?
The sheer exponential momentum of that curve suggests at 14 weeks, maybe 13 weeks, it would hit 100% efficacy. I'd still rather face delta at 100% efficacy, even if its for the former strain, than 81%. This might only be relevant to those, like me, that are already really close to the 12 weeks. I don't live in a hot zone either.Quote:
Originally Posted by Ziggurat
But those only just starting the long AZ wait it is likely better to have the second dose sooner and rely on boosters later as Mr Whippy suggested.
Quote:
Originally Posted by Ziggurat
that's good data, thank you
If you take the second dose too early, doesn't that make you less resistant to the virus from the second dose, all the way to the booster shot? You're stuck for a whole year of being more susceptible to the virus, VS being extremely susceptible for 2 months (those only starting with 1st dose recently).Quote:
Originally Posted by Ziggurat
2 months is easy to get by, like I said just lock yourself at home. No way you're gonna do that for 1 year!
With respect, so much unbridled speculation, FUD, disinformation and inappropriate medical advice in this thread.
Look I'm not against having a discussion or expressing an opinion, but giving unqualified medical advice or spreading disinfo crosses a line I feel.
Perhaps it's time for mods to shut this thread down? It's gone well beyond a useful discussion.
By what measure of logic do you decide that you are qualified to decide what "medical advice or spreading disinfo crosses a line"Quote:
Originally Posted by MisterWhippy
If you think your statement is accurate then present an alternative view with supporting evidence from verifiable sources.
Hah, nice. Nope.Quote:
Originally Posted by adahar
I sure the reason is, because the risk of catching Delta is higher and even with two doses ( with less efficiency)Quote:
Originally Posted by Ziggurat
You better at not been hospitalised than if u had only one dose
https://www.yalemedicine.org/news/co...ine-comparison
A recent write up about all of the current vaccines and how they work + how effective they are in clinical trials VS real world situations.
AZ is supposedly 93% effective at preventing hospitalisation after 2 doses. And 60% at stopping symptomatic disease (for the Delta variant).
It is not quite as good as Pfizer against Delta - 96% at preventing hospitalisation vs 88% at stopping symptomatic disease.
In short, both Pfizer and AZ are still extremely good at preventing hospitalisation and the severe symptoms of COVID. But Pfizer is a bit better at completely preventing symptoms.
Imagine
"You can punt if you're vaccinated"
We'd run out of AZ.
Why can't we have you as PM?!? :DQuote:
Originally Posted by Nabz