The most recent development in this area is that routine PSA testing is not recommended because of the risk of over-diagnosis followed by over-treatment. I've witnessed how this can make sense firsthand.

A close relo of mine detected it very early on and so went through the treatment for it. Radiotherapy, chemotherapy, hormone therapy, some sort of laser therapy, the whole shebang he went through. The result was his PSA went down to very low, but the side effects of all those treatment were incredibly severe.
ED / impotence that no meds can help with. Incontinence, bowel problems. Hot flushes. Inability to eat fruits. The list goes on.

He went to a private hospital in Asia so there's an argument to be made that they were possibly over-treating him to milk more $$$ out of him.